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- Glossary Term -

Neurofibrillary tangle

An accumulation of twisted protein (tau protein) fragments inside nerve cells. Neurofibrillary tangles are one of the characteristic structural abnormalities found in the brains of people with Alzheimer’s disease. Upon autopsy, the presence of myloid plaques and neurofibrillary tangles is used to positively diagnose Alzheimer’s disease.

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